Gary, I do wonder whether, in moving and dancing, you brought about lymphatic drainage? Lymphatic drainage, according to Mercola, enhances proprioception and ‘ translates
into a feeling of safety by allowing the brain to accurately sense joint positions and
movements, thus reducing injury risk and boosting confidence and psychological well-being’.
Okay reporting in. I have a patient not formally diagnosed with PD. He is waiting for his workup. He has a history of trauma but is in touch with his "stuff" and is open about his challenges. I did 5 sets of 2 mins freeze/unfreeze. I retested some other things we have been doing in PT and they were freer, more flexible, not frozen! His turning to the left which has been frozen was unfrozen! I saw Gary's video here and knew this was the key for this amazing person. I am not sure some of my PD patients would be so open. I am grateful for Gary's sharing his experience with the world!!! It has blown my mind! And my patient's which is way more important than how I feel!
Well that’s pretty inspiring to see, Gary, you got some moves! I know you aren’t dancing in the video, but it felt almost like a dance. Very controlled and intentional.
It’s making me want to look up some dancing in my area. That feels like a joyful physical activity.
Yes, it is a form of dance, at least it evolved from free form dancing which I was optimizing to what felt the best. I later realized that it has also converged on elements of martial arts. Kung Fu training has a lot of these fast moves and then holding the position.... What is missing in my case is the social ellement, which dance classes have the advantage of...
Thank you for this. I'm currently working through the process of attempting to reclaim my own mobility. I really appreciate this reminder of what can be done.
Thanks, Gary. I could definitely see how your movements became more fluid during that short practice. I love to dance; I find it very freeing. Also, performing in the jazz idiom allows me to learn improvisation and then apply it to other styles of music, even my own compositions. It is truly PLAYTIME!
any activity that's able to trigger one's enthousiasm will have a positive effect. and in this respect every individual will be different. some will end up doing sports, others take up some for of art or will do cooking (very therapeutic!). to find the right one is more difficult, this might take time and perhaps someone else's input.
I am seeing how the benefits of boxing helps those with PD. Or using a metronome or music with a faster beat to have people move along with that to overcome the freeze response or unlearn the unfreeze.
Yes boxing has lots of benefits for folks with PD - it is using "fight" to get out "freeze", but also burns off adrenaline and return to the calm state afterwards. There are some devices on the market [gloves and shoes] with vibrating gadgets in which help.
Thats interesting too, Gary, as, although I don’t have PD I do find myself stuck in freeze (which can then segue to dissociation) and I find using the vibroplate at the gym really helpful
Thought you might be interested in this study with all its attendant potential ramifications. with dental and surgical equipment.
PLoS Pathog
. 2024 Apr 19;20(4):e1012175. doi: 10.1371/journal.ppat.1012175. Online ahead of print.
Sensitive detection of pathological seeds of α-synuclein, tau and prion protein on solid surfaces
Christina D Orrú 1, Bradley R Groveman 1, Andrew G Hughson 1, Tomás Barrio 2, Kachi Isiofia 1, Brent Race 1, Natalia C Ferreira 1, Pierluigi Gambetti 3, David A Schneider 4, Kentaro Masujin 5, Kohtaro Miyazawa 5, Bernardino Ghetti 6, Gianluigi Zanusso 7, Byron Caughey
Abstract
Prions or prion-like aggregates such as those composed of PrP, α-synuclein, and tau are key features of proteinopathies such as prion, Parkinson's and Alzheimer's diseases, respectively. Their presence on solid surfaces may be biohazardous under some circumstances. PrP prions bound to solids are detectable by ultrasensitive real-time quaking-induced conversion (RT-QuIC) assays if the solids can be immersed in assay wells or transferred to pads. Here we show that PrP prions can remain detectable on steel wires for at least a year, or even after enzymatic cleaning and sterilization. We also show that contamination of larger objects with pathological seeds of α-synuclein, tau, and PrP can be detected by simply assaying a sampling medium that has been transiently applied to the surface. Human α-synuclein seeds in dementia with Lewy bodies brain tissue was detected by α-synuclein RT-QuIC after drying of tissue dilutions with concentrations as low as 10-6 onto stainless steel. Tau RT-QuIC detected tau seeding activity on steel exposed to Alzheimer's disease brain tissue diluted as much as a billion fold. Prion RT-QuIC assays detected seeding activity on plates exposed to brain dilutions as extreme as 10-5-10-8 from prion-affected humans, sheep, cattle and cervids. Sampling medium collected from surgical instruments used in necropsies of sporadic Creutzfeldt-Jakob disease-infected transgenic mice was positive down to 10-6 dilution. Sensitivity for prion detection was not sacrificed by omitting the recombinant PrP substrate from the sampling medium during its application to a surface and subsequent storage as long as the substrate was added prior to performing the assay reaction. Our findings demonstrate practical prototypic surface RT-QuIC protocols for the highly sensitive detection of pathologic seeds of α-synuclein, tau, and PrP on solid objects.
Gary...can I et the name of this tune? It is the beat and the metronome aspect that I am looking for. Or maybe there is someone who can suggest something to me
I'm not much of a dancer but I do enjoy me some good old
Qi gong. It also helped me loosen up my hips and shoulders which were tight from the mechanical work that I do.
https://youtube.com/@HoldenQiGong
One Person with a PD diagnosis got better through constantly practicing Qi Gong - Bianca Molle - she wrote a book........
I am thinking for those with the diagnosis of PD...they should play it at 2x speed and follow along.
I'm going to start doing your Unfreeze Dance. It makes sense. Thank you for your tenacity - it kindles my hope to beat this thing.
Let me know if it helps.
Gary, I do wonder whether, in moving and dancing, you brought about lymphatic drainage? Lymphatic drainage, according to Mercola, enhances proprioception and ‘ translates
into a feeling of safety by allowing the brain to accurately sense joint positions and
movements, thus reducing injury risk and boosting confidence and psychological well-being’.
Yes I agree this is another benefit.
Okay reporting in. I have a patient not formally diagnosed with PD. He is waiting for his workup. He has a history of trauma but is in touch with his "stuff" and is open about his challenges. I did 5 sets of 2 mins freeze/unfreeze. I retested some other things we have been doing in PT and they were freer, more flexible, not frozen! His turning to the left which has been frozen was unfrozen! I saw Gary's video here and knew this was the key for this amazing person. I am not sure some of my PD patients would be so open. I am grateful for Gary's sharing his experience with the world!!! It has blown my mind! And my patient's which is way more important than how I feel!
Wow! This is amazing and very heartwarming to hear!
Well that’s pretty inspiring to see, Gary, you got some moves! I know you aren’t dancing in the video, but it felt almost like a dance. Very controlled and intentional.
It’s making me want to look up some dancing in my area. That feels like a joyful physical activity.
Yes, it is a form of dance, at least it evolved from free form dancing which I was optimizing to what felt the best. I later realized that it has also converged on elements of martial arts. Kung Fu training has a lot of these fast moves and then holding the position.... What is missing in my case is the social ellement, which dance classes have the advantage of...
Thank you for this. I'm currently working through the process of attempting to reclaim my own mobility. I really appreciate this reminder of what can be done.
Best wishes
Thanks, Gary. I could definitely see how your movements became more fluid during that short practice. I love to dance; I find it very freeing. Also, performing in the jazz idiom allows me to learn improvisation and then apply it to other styles of music, even my own compositions. It is truly PLAYTIME!
Yes, there is much to recommend the spirit of curiosity, experimentation, and play!
any activity that's able to trigger one's enthousiasm will have a positive effect. and in this respect every individual will be different. some will end up doing sports, others take up some for of art or will do cooking (very therapeutic!). to find the right one is more difficult, this might take time and perhaps someone else's input.
Yes, curiosity and playfulness are needed to experiment and find what works for you. I agree this is very individual...
I am seeing how the benefits of boxing helps those with PD. Or using a metronome or music with a faster beat to have people move along with that to overcome the freeze response or unlearn the unfreeze.
Yes boxing has lots of benefits for folks with PD - it is using "fight" to get out "freeze", but also burns off adrenaline and return to the calm state afterwards. There are some devices on the market [gloves and shoes] with vibrating gadgets in which help.
Thats interesting too, Gary, as, although I don’t have PD I do find myself stuck in freeze (which can then segue to dissociation) and I find using the vibroplate at the gym really helpful
Love the video, Gary!
Great moves!
Dancing is awesomely healthy!
Thank you~
Loved the video.
Thought you might be interested in this study with all its attendant potential ramifications. with dental and surgical equipment.
PLoS Pathog
. 2024 Apr 19;20(4):e1012175. doi: 10.1371/journal.ppat.1012175. Online ahead of print.
Sensitive detection of pathological seeds of α-synuclein, tau and prion protein on solid surfaces
Christina D Orrú 1, Bradley R Groveman 1, Andrew G Hughson 1, Tomás Barrio 2, Kachi Isiofia 1, Brent Race 1, Natalia C Ferreira 1, Pierluigi Gambetti 3, David A Schneider 4, Kentaro Masujin 5, Kohtaro Miyazawa 5, Bernardino Ghetti 6, Gianluigi Zanusso 7, Byron Caughey
Abstract
Prions or prion-like aggregates such as those composed of PrP, α-synuclein, and tau are key features of proteinopathies such as prion, Parkinson's and Alzheimer's diseases, respectively. Their presence on solid surfaces may be biohazardous under some circumstances. PrP prions bound to solids are detectable by ultrasensitive real-time quaking-induced conversion (RT-QuIC) assays if the solids can be immersed in assay wells or transferred to pads. Here we show that PrP prions can remain detectable on steel wires for at least a year, or even after enzymatic cleaning and sterilization. We also show that contamination of larger objects with pathological seeds of α-synuclein, tau, and PrP can be detected by simply assaying a sampling medium that has been transiently applied to the surface. Human α-synuclein seeds in dementia with Lewy bodies brain tissue was detected by α-synuclein RT-QuIC after drying of tissue dilutions with concentrations as low as 10-6 onto stainless steel. Tau RT-QuIC detected tau seeding activity on steel exposed to Alzheimer's disease brain tissue diluted as much as a billion fold. Prion RT-QuIC assays detected seeding activity on plates exposed to brain dilutions as extreme as 10-5-10-8 from prion-affected humans, sheep, cattle and cervids. Sampling medium collected from surgical instruments used in necropsies of sporadic Creutzfeldt-Jakob disease-infected transgenic mice was positive down to 10-6 dilution. Sensitivity for prion detection was not sacrificed by omitting the recombinant PrP substrate from the sampling medium during its application to a surface and subsequent storage as long as the substrate was added prior to performing the assay reaction. Our findings demonstrate practical prototypic surface RT-QuIC protocols for the highly sensitive detection of pathologic seeds of α-synuclein, tau, and PrP on solid objects.
Gary...can I et the name of this tune? It is the beat and the metronome aspect that I am looking for. Or maybe there is someone who can suggest something to me